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Qué (quién) es T cell receptor revision - definición
T cell receptor revision
T-cell receptor revision (alternative term: antigen receptor editing) is a process in the peripheral immune system which is used by mature T cells to alter their original antigenic specificity based on rearranged T cell receptors (TCR). This process can lead either to continuous appearance of potentially self-reactive T cells in the body, not controlled by the central tolerance mechanism in the thymus or better eliminate such self-reactive T cells on the other hand and thus contributing to peripheral tolerance - the extent of each has not been completely understood yet.
T-cell receptor
MOLECULE FOUND ON THE SURFACE OF SOME IMMUNE CELLS
Alpha-beta T-cell antigen receptor; Genes, t-cell receptor; T-cell receptors; Receptors, antigen, t-cell; T-cell antigen receptors; TCRδ1; TCRd1; T cell receptor
The T-cell receptor (TCR) is a protein complex found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. The binding between TCR and antigen peptides is of relatively low affinity and is degenerate: that is, many TCRs recognize the same antigen peptide and many antigen peptides are recognized by the same TCR.
Naive T cell
CELL TYPE
Naive T cells; Th0 cell; Naive t cell; Th0; T-helper zero; Naive T-cell; Naive T-cells; Naïve T cell; Naïve T cells
A naive T cell (Th0 cell) is a T cell that has differentiated in the thymus, and successfully undergone the positive and negative processes of central selection in the thymus. Among these are the naive forms of helper T cells (CD4+) and cytotoxic T cells (CD8+).
